Close

Delete Collection?

Are you sure you want to delete this collection permanently?

Close

Delete Collection?

Are you sure you want to delete this collection permanently?

d9093947-ed94-44f4-b4fd-c8b767343517

Novel drug may offer treatment for tuberculosis

The findings showed that the compound does not kill the bacteria directly, but results in a significant reduction in the bacterial burden.

719341-drug-1070943960720pixabay

London: In first, British scientists have developed a non-antibiotic drug that can one day successfully treat tuberculosis (TB) in humans.

The drug, developed by the University of Manchester, works by targeting Mycobacterium tuberculosis` (Mtb) defenses rather than the bacteria itself. It can also take out its increasingly commonly antibiotic-resistant strains.

In the study, published in the Journal of Medicinal Chemistry, animals with acute and chronic TB infection were treated with the compound.

The findings showed that the compound does not kill the bacteria directly, but results in a significant reduction in the bacterial burden.

"For more than 60 years, the only weapon doctors have been able to use against TB is antibiotics. But resistance is becoming an increasingly worrying problem and the prolonged treatment is difficult and distressing for patients," said Lydia Tabernero, Professor from the varsity.

"But by disabling this clandestine bacteria`s defences we`re thrilled to find a way that enhances the chances of the body`s immune system to do its job, and thus eliminate the pathogen," Tabernero said.

Mtb secretes molecules called Virulence Factors the cell`s secret weapon, which blocks out the immune response to the infection, making it difficult to treat.

The team identified one Virulence Factor called MptpB as a suitable target, which when blocked allows white blood cells to kill Mtb in a more efficient way.

"The great thing about MptpB is that there`s nothing similar in humans so our compound which blocks it is not toxic to the human cells," Tabernero said.

"Because the bacteria hasn`t been threatened directly, it is less likely to develop resistance against this new agent, and this will be a major advantage over current antibiotics, for which bacteria had already become resistant," he explained.

The researchers hope for clinical trials in humans up in four years.

Categories

Others
Related Articles

The love for flying starts at a time when most of us are young. It can start by simply getting excited whenever a plane flies overhead, or reading about them and developing more of an interest in aviation. The concept of flying ignites such a passion in some people that they want to pursue their dreams and become pilots. From there, it is only a matter of time before you start taking the first steps towards looking into a commercial airline pilot school and obtaining a pilot licence.

The road can be long and there are a lot of steps you need to take, so to give you a better insight, this guide is what an average pilot goes through before working for an airline.

Flight training usually begins with studying an RPL (Recreational Pilot Licence), which entails flight theory, learning the basic controls, simulation and aircraft training and the first live experience you will ever get in a cockpit. What follows depends on what you want to get out of flying, whether it is for pleasure or as a profession. The CPL (Commercial Pilot Licence) course is for students wanting to get paid for their flying services and the PPL (Private Pilot Licence) course is for students wanting to fly for fun.

Some airlines now offer cadetship roles that have no minimum hourly requirement, but it is still a good idea to gain a reasonable level of aviation experience and knowledge before applying. For standard entry into an airline pilot role, there are required flight hours and experience that need to be obtained before you can successfully pilot a big commercial airliner.

A good way to earn those hours and the necessary experience is by becoming a flight instructor. This way you get to sharpen and refresh your skills and at the same time you also get to impart valuable knowledge to a fellow enthusiast. It is also possible to obtain work as a charter pilot, and this can give you a great opportunity to travel and see some fantastic places in the country whilst gaining the needed experience and flight hours.

When you are at the required level to consider airline pilot jobs, it is highly advisable to enrol in an Airline Interview Coaching Session or a Cadet Pilot Interview Workshop. These give you an in-depth look at what airlines are looking for, giving you a huge advantage over other applicants in what can be a very competitive recruitment process. The topics the courses cover can include technical assessments, flight control systems training, the various stages of the airline interview process and much more.

Once you are selected by an airline, the job role and lifestyle is extremely rewarding. You will visit a lot of places all over the world and get to enjoy the sights and sounds of different countries. Almost anyone who has been an airline pilot would recommend it as a career in a heartbeat! When looking for a commercial airline pilot school, Learn to Fly has a range of courses designed for students looking to fly for fun or professionally. Browse their website for all the information you need to pick a course that is right for you today!

Reference Image
Close