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Know About 2-Aminopyridine And Its Properties?

2-Aminopyridine derivatives prepared by reacting a quaternary ammonium compound with malononitrile in the appearance of an alkanol, replaced by reaction with ammonia in the behavior of an alkanol, water and ether to give aminonicotinonitrile and, if wanted, then reacting this product with an alkali metal compound to provide aminonicotinic acid.

The 2-aminopyridine derivatives available by the process of the invention are valuable starting materials for the preparation of pesticides, drugs, vitamins, and dyes.

Product Information:

CAS number 504-29-0

EC number 207-988-4

Hill Formula C₅H₆N₂

Chemical formula 2-(NH₂)C₅H₄N

Molar Mass 94.11 g/mol

HS Code 2933 39 99

The prepared invention relates to a process for the preparation of 2-aminopyridine derivatives by reacting a quaternary ammonium compound with malononitrile in the appearance of an alkanol, followed by reaction with ammonia in the attendance of an alkanol, water and/or an ether to give aminonicotinonitrile and, if wanted, then reacting this product with an alkali metal compound to provide aminonicotinic acid.

The formation of quaternary ammonium compounds, which are also derivatives of malonaldehyde, of the formula ##STR1## where R4 is alkyl and R5 is alkyl or H, by using phosgene with a dialkyl formamide to give a dialkylformamidechloride and then reacting the product with an enol ether has been disclosed (German Laid-Open Application DOS 2,424,373).

Moreover, it is known (Synthesis 1979, pages 376 to 378) that alkylidene malodinitriles can be found with lithium-diisopropylamide in tetrahydrofuran at -65° C. and the product then replied with dimethylformamide dichloride to give 4-dimethylamino-1,3-butadiene-1,1-carbonitrile. These butadiene mixtures can be changed to 2-aminopyridines by reaction with ammonia in methanol.

Similarly, as reported in German Laid-Open Application DOS 1,811,973, 2-amino-5,6-dihydro-4-methylthiobenzoquinoline-3-carbonitrile is obtained by reacting 2-methylthio-2-(3,4-dihydro-1-pyrrolidine-2-naphthyl)-ethylene-1,1-dicarbonitrile with aqueous ammonia in the presence of methanol.


It observed that 2-aminopyridine derivatives of the formula ##STR2## where R1 is cyano or carboxyl, are advantageously obtained if a quaternary ammonium compound of the formula ##STR3## where the different radicals R2 and R3 can be identical or different and each is an aliphatic radical,

(a) is found with malononitrile in the presence of an alkanol,

(b) the resulting reaction mixture is then exposed with ammonia in the presence of an alkanol, water, and ether and if desired,

(c) the aminonicotinonitrile thus obtained is taken with an alkali metal compound.


Related Categories Alphabetical, Biochemicals and Building Blocks, Reagents, C5,

Chemical Synthesis


assay 99%

bp 204-210 °C(lit.)

mp 54-58 °C (lit.)

Safety Information:

Signal word Danger

Hazard statements H301 + H311-H315-H319-H335

Precautionary statements P261-P280-P301 + P310-P305 + P351 +


Personal Protective Equipment Face Shields, Eyeshields, Gloves, type P2 (EN 143)

respirator cartridges

RIDADR UN 2671 6.1 / PGII

WGK Germany 3

RTECS US1575000

Flash Point(F) 197.6 °F

Flash Point(C) 92 °C

R Phrase R 23/24/25-51/53

Toxic by inhalation, in touch with skin and if eaten. Toxic to aquatic organisms, may cause long-term adverse results in the marine environment.

In case of touch with eyes, rinse quickly with plenty of water and seek medical advice. Wear proper protective clothing and gloves. In case of disaster or if you feel unwell, ask medical advice quickly (show the label where possible). Avoid release to the situation. Refer to individual instructions/ Safety data sheets. There are many API manufacturers in global that provide all the states to utilize.

Application: 2-Aminopyridine for structure. CAS 504-29-0, analytic formula 2-(NH₂)C₅H₄N.

Related Articles

If someone who had a painful childhood was to talk about what took place to another person, they may end up being told that they need to forgive their parents. This could be something that they come out with more or less straight away or it may have taken a while.

Furthermore, one could be told that what they went through is all in the past and now they need to put it behind them. And that if they don’t do this, it will stop them from being able to live a good life.

A Heavy Weight

Thus, in the same way that an anchor will stop a ship from moving forward, their attachment to the past will do the same thing. The sooner they are able to see this, the sooner they will be able to let go of what took place all those years ago.

Forgiving their parents for what happened is going to be essential if they want to let go of the pain that they are in and to experience inner peace. This could be something that takes place directly or they could write a letter and send it to them.

Positive Feedback

Once this has taken place, they may find that they start to feel better. Also, the person who told them to do this, along with a number of other people, could say that they did the right thing.

The days and weeks could go by and their life could continue to improve, with it being clear that they made the right decision. Then again, what they may find is that they have simply pushed down their true feelings and are living in denial.

A Different Approach

Although forgiveness was put forward as the solution to what they were going through, it doesn’t mean it is the right solution. One way of looking at it would be to say that it doesn’t matter whether they forgive their parents or not; what matters is that they heal their inner wounds.

A number of years may have passed since they were a child, but the pain that they experienced during this time is still going to be held in their body. And, unless they work through this pain, it is likely to be more or less impossible for them to move on.

Crying Out

A big part of them – their inner child – is going to be in a lot of pain, and this part of them will want to be acknowledged and to express all of the pain that it has carried for so long. Unsurprisingly, they are not going to resolve this pain by simply forgiving their parents.

If their emotional pain was solely caused by the thoughts in their head, this approach might work. Yet, as emotional pain is held in their body, changing their thoughts is not going to get to the root of what they are experiencing.

Final Thoughts

By healing their inner wounds, they may start to experience compassion towards their parents. If so, they won’t need to force themselves to forgive them; it will be a by-product of healing themselves.

They may also gradually come to see their parents are just flawed human beings, not as gods. This would show that they are seeing them through adult eyes, as opposed to the eyes of their wounded inner child.

​If someone is in a lot of pain, and they want to heal their winner wounds, they may need to reach out for external support. This is something that can be provided by the assistance of a therapist or a healer. 

About Author

The definition of beauty differs from individual to individual, but in order to look beautiful everyone will follow for sure. Most people feel that being beautiful means having white teeth. There is a difference between people who have proper dentitions and people who don’t have; they can confidently smile in public while others don’t. There’s always something that won’t agree with our personality it can be anything like discoloration of tooth, damages and many more. Worrying about these things can be very unnatural but due to cosmetic procedures, it can be easily solved.

Increasing popularity

Unlike regular dentistry cosmetic dental provides treatments related to augmenting the appearance of gums & teethes. There has been heightened incoming of people towards a specialized process. It may not be preferably done for health reasons instead to improve personal image and style. Invasive treatments have been less when compared to other dental methods; this is also one of the factors for increased incoming of people. Due to painless treatments outcomes have been very proficient.

Function & appearance

In an oral maxillofacial profession, aesthetic practices are found to be more mainstream as well as well known disciplines because many public opinions carry a view that undergoing enhancive medical procedures. It may not be considered as a specialized part of studying but it doesn’t stop experts from calling themselves as cosmetic dentists. These professionals are experts in general practices, orthodontics, and prosthetics.

Entailing the prevention of various oral problems, appearances of teeth and skeletal abnormalities are all comes under those three fields. They indulge in diagnosing signs and symptoms of oral problems also providing solutions with superficial surgeries. Regardless of enhancive dentistry, those domains vary from each other.

Selecting qualified professional

In accordance to perform these skills, a doctoral candidate should have the highest level of training; technical competence and rigorous program of post-graduate training are required. A vast majority of educational institutions doesn’t provide any courses related to this domain. It is important for a practitioner to complete continuously a series of courses. The discipline of superficial dentistry is regularly changing its course what was popular in previous time was not now. For getting proper results profound training is essential to learn about recent techniques & types of equipment.



Enhancing process is an important advantage apart from providing aesthetical alternations in this superficial field. It helps to align the teeth in a proper way to optimize its proficiency. If there is a situation relating to missing or broken dentition enhancive medical service can be a suitable option.

Immediate results:

A huge benefit for this industry is that of quick outcomes When implants are being used it will take time to see its results but in enhancive methods, even a small process like whitening treatments will show quicker results.


Various forms of operations are done to replace the structure of a tooth that has been damaged or has tooth decay. Some of the solutions provided in this field are solely for aesthetical purpose while other forms are for strengthening.

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